Wild, C. (2012): Avastin for Age-related Macular-Degeneration. Evidence synthesis after CATT, IVAN, MANTA. Rapid Assessment 005.
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Background: Synthesis of evidence on the efficacy and safety of Avastin for AMD
Method: Assessment of three head-to-head RCTs on Avastin for AMD
Results: Since the publication of now three head-to-head randomised clinical studies / RCTs (CATT, IVAN, MANTA), evidence meeting the highest methodological requirements is available. The efficacy is regarded – not least by these RCTs – as proven. According to CATT, IVAN and MANTA, a discussion about the equivalence is no longer necessary, but probably about the monthly vs. needs-oriented administration strategy, since with the latter the intravitreal injections have to be administered considerably less frequently.
Conclusion: A legal regulation is urgently pending in Austria in order to place evidence-based, off-label application on a legal foundation (with regard to liability and insurance laws).
|Item Type:||Rapid Assessment LBI-HTA|
|Keywords:||AMD, Age-related Macular Degeneration, off-label use, Avastin, Bevacizumab, Ophthalmology|
|Subjects:||WW Ophthalmology > WW 270 Retina|
WB Practice of medicine > WB 60 Bioethics. Clinical ethics. Clinical ethics committees
W Health professions > W 74-80 Medical economics. Health care costs
WB Practice of medicine > WB 102 Evidence-based medicine
QV Pharmacology, toxicology, pharmacy > QV 60-370 Pharmacology
WW Ophthalmology > WW 101-170 Eye
|Series Name:||Rapid Assessment 005|
|Deposited on:||21 Jan 2013 15:38|
|Last Modified:||23 Jan 2013 12:36|
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