Fischer, S. and Zechmeister-Koss, I. (2012): Radiofrequency Ablation for the Treatment of Breast Cancer. Decision Support Document 57.
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This systematic review evaluated radiofrequency ablation (RFA) for the treatment of breast cancer. A systematic literature search in various databases was supplemented by a handsearch.
We identified six prospective (uncontrolled) case series with 206 patients with breast cancer as best available evidence. Concerning efficacy, the overall survival rate was 100% and the recurrence rate was 0% (both outcomes were only assessed in one case series including 29 patients). Cosmetic results were good in 80-97% of the patients. There is a lack of evidence for further efficacy outcomes (breast cancer-specific survival, quality of life). In terms of safety, minor complications like skin or muscle burns occurred in up to one third of patients. There was no RFA-associated mortality.
The quality of evidence is very low due to the uncontrolled study design of the included studies. Overall, the available evidence is insufficient to assess the efficacy and safety of RFA compared to the respective standard therapy for the treatment of breast cancer.
|Item Type:||Decision Support Document|
|Keywords:||Radiofrequency ablation, RFA, tumor ablation, tumour ablation, breast cancer, mamma carcinoma|
|Subjects:||WP Gynaecology > WP 800-910 Breast|
WO Surgery > WO 500-517 Operative surgical procedures. Techniques
WO Surgery > WO 505 Minimally invasive surgical procedures
|Series Name:||Decision Support Document 57|
|Deposited on:||23 Jul 2012 19:57|
|Last Modified:||25 Sep 2012 12:42|
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