LBI-HTA - Publications - Search - Erlotinib (Tarceva®) for the first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer with EGFR activating mutations

Nachtnebel, A. (2012): Erlotinib (Tarceva®) for the first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer with EGFR activating mutations. DSD: Horizon Scanning in Oncology 22.

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Abstract

Erlotinib, a tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR), was licensed for maintenance therapy after first-line chemotherapy and after failure of at least one prior chemotherapy regimen for non-small cell lung cancer. In July 2011, the Committee for Medicinal Products for Human Use of the EMA recommended an extension of indication for erlotinib as first-line treatment of patients with locally advanced or metastatic NSCLC with EGFR activating mutations. Two phase III trials were found for this indication, both showing improved outcomes for progression free survival for patients treated with erlotinib in comparison to standard platinum-based chemotherapy. Despite distinct differences, toxicity profiles were also more favourable for erlotinib. However, no information regarding impact on overall survival was available and data for quality-of-life were very limited. Open questions concern methods for determining EGFR mutation status as well as characteristics associated with resistance to erlotinib.

Item Type:DSD: Horizon Scanning in Oncology
Keywords:Non-small cell lung cancer, NSCLC, advanced, Tarceva, erlotinib, EGFR, tyrosine kinase inhibitor
Subjects:WB Practice of medicine > WB 300-962 Therapeutics
QZ Pathology > QZ 200-380 Neoplasms.Cysts
WF Respiratory system
QV Pharmacology, toxicology, pharmacy > QV 60-370 Pharmacology
Language:English
Series Name:DSD: Horizon Scanning in Oncology 22
Deposited on:07 Feb 2012 14:06
Last Modified:07 Feb 2012 16:44

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