Hintringer, K. (2011): Panitumumab (Vectibix®) as 1st-line combination therapy for the treatment of WT KRAS metastatic colorectal cancer - 1st Update 2011. DSD: Horizon Scanning in Oncology 11 / Update 2011.
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In June 2011, the European Medicines Agency (EMA) extended the licensed indication for panitumumab (Vectibix®), a monoclonal antibody targeting the epidermal growth factor receptor (EGFR) to first- and second-line therapy in combination with chemotherapy in patients with non-mutated(wild-type, WT) KRAS (WT KRAS) metastatic colorectal cancer (mCRC).
Overall, two studies reporting results on panitumumab therapy in WT KRAS patients were identified. One study (PACCE) was halted after the first interim analysis based on inferior progression free survival (PFS) results and increased toxicity caused by the combination of two monoclonal antibodies. Even though the second trial (PRIME) could not show prolongation regarding overall survival, the PFS was statistically significantly longer when panitumumab was added to chemotherapy in WT KRAS patients compared to chemotherapy alone. As expected, adverse events were more frequent and more severe in the panitumumab arm, but were considered to be clinically manageable. Further, the PRIME trial confirmed that even though panitumumab targets the EGFR, KRAS status is currently the most important predictive factor for response to panitumumab.
Currently there are several different drugs and classes of drugs available for the treatment of mCRC. One of the future challenges will thus be to identify the optimal sequence, combination and duration of these drugs.
|Item Type:||DSD: Horizon Scanning in Oncology|
|Keywords:||metastatic colorectal cancer mCRC panitumumab Vectibix oncology|
|Subjects:||WB Practice of medicine > WB 300-962 Therapeutics|
WI Digestive system > WI 400-560 Intestines
QZ Pathology > QZ 200-380 Neoplasms.Cysts
QV Pharmacology, toxicology, pharmacy > QV 60-370 Pharmacology
|Series Name:||DSD: Horizon Scanning in Oncology 11 / Update 2011|
|Deposited on:||23 Nov 2011 16:40|
|Last Modified:||23 Feb 2012 17:04|
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