Nachtnebel, A. (2011): Second-line chemotherapy with cabazitaxel (Jevtana®) for the treatment of castration-resistant metastatic prostate cancer. DSD: Horizon Scanning in Oncology 16.
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Cabazitaxel, a new molecular entity, is indicated as 2nd-line therapy for patients with metastatic castration- resistant prostate cancer. Cabazitaxel is licensed in the U.S. and received a positive opinion of the EMA’s Committee for Medicinal Products for Human Use based on the results of a phase III trial which investigated cabazitaxel + prednisone in comparison to mitoxantrone + prednisone. Median overall survival showed a statistically significant improvement for patients treated with cabazitaxel in comparison to mitoxantrone (HR=0.70, p<0.0001). However, the difference was only 2.4 months in comparison to a drug with an unknown impact on survival itself. Also, as this new therapy is associated with frequent and sometimes life-threatening adverse events, data on quality-of-life, which are still missing, are of utmost interest. Further questions which need to be addressed are the efficacy of cabazitaxel in comparison to docetaxel in the 1st-line setting.
In summary, reliable estimates of the drug’s true significance are not possible to date.
|Item Type:||DSD: Horizon Scanning in Oncology|
|Additional Information:||This report is the product of a collaboration with the HTA Center Bremen (Germany), an offspring of the European network for Health Technology Assessment (EUnetHTA) Project that was supported by a grant from the European Commission. The responsibility lies with the author(s)solely, the European Commission is not responsible for any use that may be made of the information contained therein.|
|Keywords:||Prostate cancer, chemotherapy, hormone-refractory, castration-resistant, 2nd-line, second-line, Cabazitaxel, Jevtana|
|Subjects:||WJ Urogenital system > WJ 700-875 Male genitalia|
QZ Pathology > QZ 200-380 Neoplasms.Cysts
QV Pharmacology, toxicology, pharmacy > QV 60-370 Pharmacology
|Series Name:||DSD: Horizon Scanning in Oncology 16|
|Deposited on:||12 Apr 2011 16:54|
|Last Modified:||02 May 2011 15:25|
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