LBI-HTA - Publications - Search - Trastuzumab (Herceptin®) in addition to standard chemotherapy as first-line therapy for advanced gastric cancer

Schott, G. (2010): Trastuzumab (Herceptin®) in addition to standard chemotherapy as first-line therapy for advanced gastric cancer. DSD: Horizon Scanning in Oncology 12.

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Abstract

In January 2010, the European Medicines Agency (EMA) extended the indication for the use of trastuzumab (Herceptin®), a humanised monoclonal antibody that binds to the human epidermal growth factor 2 (HER2) protein, for the first line treatment of patients with HER2 positive metastatic adenocarcinoma of the stomach or gastroesophageal junction. The decision was based on one phase III study, which showed improved overall survival of patients treated with trastuzumab in combination with standard chemotherapy (5-FU or capecitabine plus cisplatin) compared to patients treated with standard chemotherapy alone. Despite limitations of the available data, it is reasonable to offer trastuzumab in addition to standard chemotherapy to patients with tumours expressing high levels of HER2 protein, as long as they do not have a contraindication to trastuzumab.

Item Type:DSD: Horizon Scanning in Oncology
Keywords:gastric cancer, trastuzumab, oncology, HER2, adenocarcinoma, cancer
Subjects:WB Practice of medicine > WB 300-962 Therapeutics
WI Digestive system > WI 300-387 Stomach
QZ Pathology > QZ 200-380 Neoplasms.Cysts
QV Pharmacology, toxicology, pharmacy > QV 60-370 Pharmacology
Language:English
Series Name:DSD: Horizon Scanning in Oncology 12
Deposited on:14 Jul 2010 12:30
Last Modified:14 Jul 2010 12:30

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