LBI-HTA - Publications - Search - Clinical application of Tissue Engineering: An overview of International and Austrian Areas of Research with a critical analysis of selected applications

Falkner, E. and Wild, C. (2008): Clinical application of Tissue Engineering: An overview of International and Austrian Areas of Research with a critical analysis of selected applications . LBI-HTA Projektbericht 013.

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Abstract

Background: In the past 15 years, important innovations have been made in biomedical and (molecular-) biology research domains by combining cell biology techniques for the guided generation of tissue. The term `Tissue En-gineering´ (TE) was created for these applications, which beside of basic re-search interest are of clinical relevance. Concerning the high costs, critics demand valid proof for the many promises made.
International legislation on clinical TE usage varies, harmonisations are in force just for certain aspects or are discussed at the moment.

Method: Chosen method for the generation of this report is the systematic literature review with special regard to `Grey Literature´, which in this con-text stands for publications not available by regular book and journal distri-bution. Examples for Grey Literature are conference proceedings, scripts, preprints, catalogues, web presence and papers out of the university settings not published yet.

Results: The investigations uncovered beside a large amount of TE experi-ments in varying states of research just a surprisingly small number of clini-cal TE studies or case studies documenting actual clinical usage of TE methods in human medicine. Austria-specific TE topics, research groups, bio banks and the generation of TE clusters could be documented.

Discussion: Tissue Engineering (TE) is defined as the biomedical application of cells, in the majority of cases in combination with a growth and differen-tiation stimulating matrix for tissue regeneration purposes in patients with varying diseases or injuries. Definitions overlap with `Regenerative Medi-cine´ (RM), `Future Medicine´ and `Advanced Therapies´. Examples for clinical application include chondrocyte implantation, skin substitutes, repair of bone defects and cell seeding of cardiovascular stents.
Objective is a summary of the state of the art of TE research with attention to clinical relevance, the documentation of Austrian research clusters and bio banks. Furthermore an evaluation of selected fields of application regarding costs and benefits for patients is made.

Item Type:Project Report
Keywords:tissue engineering clinical
Subjects:WD Disorders of systemic, metabolic or environmental origin > WD 200-226 Metabolic diseases
QU Biochemistry > QU 450-500 Genetics
WK Endocrine system > WK 700-790 Adrenal glands
QU Biochemistry > QU 75-99 Carbohydrates. Lipids
WE Musculoskeletal system > WE 800-890 Extremities and podiatry
WV Otolaryngology > WV 200-290 Ear
WV Otolaryngology > WV 300-358 Nose and paranasal sinuses
WI Digestive system > WI 900-970 Abdomen
WJ Urogenital system > WJ 140-160 Urologic diseases
WE Musculoskeletal system > WE 500-600 Muscles and tendons
QU Biochemistry > QU 135-144 Enzymes
WW Ophthalmology > WW 270 Retina
WL Nervous system > WL 500-544 Peripheral nerves
WO Surgery > WO 600-640 Plastic surgery
WE Musculoskeletal system > WE 700-715 Head and trunk
QU Biochemistry > QU 55-70 Proteins. Amino Acids. Peptides
WL Nervous system > WL 600-610 Autonomic nervous system
WI Digestive system > WI 600-650 Anus. Rectum
QW Microbiology. Immunology
WJ Urogenital system > WJ 400-600 Ureter. Bladder. Urethra
WI Digestive system > WI 400-560 Intestines
WH Hemic and lymphatic systems
WL Nervous system > WL 200-405 Central nervous system. Disorders. Therapeutics
WI Digestive system > WI 250 Oesophagus
WW Ophthalmology > WW 101-170 Eye
WO Surgery > WO 660-690 Transplantation
QT Physiology > QT 261 Sports medicine
WE Musculoskeletal system > WE 300-400 Joint tissues
WE Musculoskeletal system > WE 200-259 Bones
QV Pharmacology, toxicology, pharmacy > QV 600-667 Toxicology
WO Surgery > WO 925 Paediatric surgery
QT Physiology > QT 36-37 Biomedical engineering, nanotechnology, biocompatible materials
WL Nervous system > WL 700-710 Sense organs
WI Digestive system > WI 800-830 Pancreas
WI Digestive system > WI 300-387 Stomach
WU Dentistry. Oral surgery
QU Biochemistry > QU 300-375 Cells
WV Otolaryngology > WV 500-540 Larynx
WF Respiratory system
WI Digestive system > WI 700-770 Liver. Billary tract
WK Endocrine system > WK 200-300 Thyroid gland. Parathyroid gland
QV Pharmacology, toxicology, pharmacy > QV 38 Pharmacogenetics
WE Musculoskeletal system > WE 720-755 Back
WO Surgery > WO 185 Wound healing
WK Endocrine system > WK 800-920 Islets of Langerhans and gonads
WG Cardiovascular system
QV Pharmacology, toxicology, pharmacy > QV 247-269 Anti-inflammatory agents. Anti-infective agents
WV Otolaryngology > WV 400-440 Pharyngeal region
WJ Urogenital system > WJ 300-378 Kidney
WE Musculoskeletal system > WE 168-190 Orthopedics
QV Pharmacology, toxicology, pharmacy > QV 60-370 Pharmacology
WR Dermatology
Language:German
Series Name:LBI-HTA Projektbericht
Number:013
Deposited on:17 Oct 2008 22:17
Last Modified:29 Jun 2009 13:25

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