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Goetz, G. and De Villiers, C. (2019): Allograft for anterior and posterior cruciate ligament reconstruction. Decision Support Document 116.

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Abstract

This report evaluated the effectiveness and safety of allograft cruciate ligament reconstruction compared to other cruciate ligament reconstruction technologies, e.g. autografts or conservative management in five indications. Evidence for effectiveness and safety comparing these allografts with autografts was found for three of the indications.

In total, eight randomised controlled trials and one comparative cohort study met the eligibility criteria for the synthesis. The strength of evidence is very low to low. For Anterior Cruciate Ligament Reconstructions (ACLR), allografts may be comparable in terms of effectiveness but may be less safe due to potentially higher graft failures. For Posterior Cruciate Ligament Reconstructions (PCLR), effectiveness may be comparable yet there was insufficient evidence for the comparative safety. No evidence was found for the remaining two indications nor for comparing allografts with conservative management.
Therefore the inclusion is not currently recommended in the Austrian benefits catalogue.

Item Type:Decision Support Document
Keywords:Allograft cruciate ligament reconstruction, autograft cruciate ligament reconstruction, ACLR, PCLR, graft failure, revision reconstruction
Subjects:WB Practice of medicine > WB 300-962 Therapeutics
WE Musculoskeletal system > WE 300-400 Joint tissues
QT Physiology > QT 250-275 Leisure Activities. Sports Medicine > QT 261 Sports medicine
QT Physiology > QT 34-37 Physics. Mathematics. Engineering > QT 36-37 Biomedical engineering, nanotechnology, biocompatible materials
W Health professions > W 100-275 Medical, dental and pharmaceutical service plans
WO Surgery > WO 500-517 Operative surgical procedures. Techniques
WE Musculoskeletal system > WE 500-600 Muscles and tendons
WO Surgery > WO 660-690 Transplantation
WE Musculoskeletal system > WE 168-190 Orthopedics
Language:English
Series Name:Decision Support Document 116
Deposited on:15 Jul 2019 08:40
Last Modified:29 Jul 2019 18:51

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