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Hawlik, K. and Wild, C. (2017): Extracorporeal cytokine haemadsorption in patients with sepsis or SIRS. Decision Support Document 105.

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Abstract

Extracorporeal cytokine adsorption therapy (ECAT) aims to reduce the cytokine concentration in the blood, thereby stabilising the overall immune response in sepsis and SIRS (Systemic Inflammatory Response Syndrome). We investigated the efficacy and safety of ECAT in its two main indications: to treat sepsis and to prevent SIRS during cardiopulmonary bypass surgery (CPB).

Overall, three studies were identified that contained clinical data on ECAT. However, no data for the assessment of ECAT in patients with sepsis and septic shock were available. The overall quality of the studies on the preventive use during CPB was classified as very low. No conclusions could be drawn as to whether ECAT is a safe and effective intervention. We therefore do not recommend inclusion of ECAT in the Austrian BMG benefit catalogue and suggest a re-evaluation should randomised controlled trials in both indications become available.

Item Type:Decision Support Document
Keywords:Sepsis, septic shock, SIRS, extracorporeal therapy, cytokines, cardiopulmonary bypass
Subjects:WB Practice of medicine > WB 300-962 Therapeutics
W Health professions > W 100-275 Medical, dental and pharmaceutical service plans
WX Hospitals and other health facilities > WX 218 Intensive care units. Critical care (General)
WD Disorders of systemic, metabolic or environmental origin > WD 300-375 Immunologic and collagen diseases
WH Hemic and lymphatic systems
Language:English
Series Name:Decision Support Document 105
Deposited on:17 Jul 2017 12:06
Last Modified:17 Jul 2017 12:06

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