Fischer, S. (2016): Single-step scaffold-based cartilage repair in the knee. Decision Support Document 98.
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In this report, we analysed whether single-step scaffold-based cartilage repair in combination with microfracturing (MFx) is more effective and safe in comparison to microfracturing alone, or as effective but safer in comparison to (matrix-induced) autologous chondrocyte implantation.
In total, data from three controlled trials that met our inclusion criteria were extracted. It appears that single-step scaffold-assisted cartilage repair in combination with MFx leads to similar short to medium-term (up to five years follow-up) results, compared to MFx alone. Overall, the strength of the evidence was low.
At the moment, it seems too early to include single-step scaffold-assisted cartilage repair of the knee in the Austrian catalogue of benefits. A re-evaluation is recommended for 2018 at the earliest.
|Item Type:||Decision Support Document|
|Keywords:||Cartilage defects, microfracturing, autologous chondrocyte implantation, chondrogenesis, AMIC|
|Subjects:||WB Practice of medicine > WB 300-962 Therapeutics|
W Health professions > W 100-275 Medical, dental and pharmaceutical service plans
WE Musculoskeletal system > WE 300-400 Joint tissues
WE Musculoskeletal system > WE 168-190 Orthopedics
WE Musculoskeletal system > WE 800-890 Extremities and podiatry
|Series Name:||Decision Support Document 98|
|Deposited on:||14 Jul 2016 23:48|
|Last Modified:||14 Jul 2016 23:48|
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