LBI-HTA - Publications - Search - Hadron therapy in children: evidence synthesis for 15 paediatric tumours. Report based on Belgian (KCE) HTA report

Wild, C. (2015): Hadron therapy in children: evidence synthesis for 15 paediatric tumours. Report based on Belgian (KCE) HTA report. Decision Support Document 88.

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Abstract

A Belgian KCE-Assessment analysed –as an update of the 2007 report– the evidence for hadron therapy (proton and carbon ions) in 15 paediatric indications. As the Austrian MedAustron started operating in 2015 and the first patients are being treated, the external expertise of the LBI-HTA was included in the updated Belgian report. Now the LBI-HTA has –due to its regional relevance– produced a German summary of the KCE report.

In the assessment 21 clinical studies (non-randomised, non-controlled and mostly retrospective) were found. All studies showed serious methodological flaws. The conclusion therefore is that all paediatric cancers under investigation are lacking clinical data on PBT as well as critical information on long-term effectiveness and harms. Prospective comparative clinical trials in the field are urgently needed.

Item Type:Decision Support Document
Keywords:Proton Therapy, Hadron Therapy, radiotherapy, cancer, oncology, children
Subjects:WB Practice of medicine > WB 300-962 Therapeutics
WS Pediatrics
W Health professions > W 100-275 Medical, dental and pharmaceutical service plans
WB Practice of medicine > WB 102 Evidence-based medicine
QZ Pathology > QZ 200-380 Neoplasms.Cysts
Language:German
Series Name:Decision Support Document 88
Deposited on:19 Feb 2015 19:39
Last Modified:19 Feb 2015 19:43

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